Applications of Ultrasound Focusing Systems Based on Time Reversal Acoustics Principles

Time Reversal Acoustics (TRA) is a novel concept introduced by Mathias Fink of the University of Paris for focusing and steering acoustic beams in complex heterogeneous media. Scattering, refractions and reflections in highly inhomogeneous media, which distort focusing in conventional acoustic focusing systems and are viewed as a significant technical hurdle, lead to improvement of the focusing ability of the TRA system. Thus, TRA takes advantage of these usually undesirable processes. Artann Laboratories has developed a family of TRA electronic systems for a variety of medical and non-medical applications based on TRA principles. These projects were supported by several grants from NIH, NASA and DoD. Artann has numerous issued and pending US patents on various applications of TRA and results of the studies were presented in numerous publications and presentations.

Grants, Patents

Grant support
  • R21CA164935-01, Sarvazyan (Co-Investigator), Olbricht (PI), Ultrasound-assisted convection-enhanced drug delivery to the brain, 03/01/2012 - 02/28/2014
  • R43NS065524, Sarvazyan (PI), Time-reversal acoustic device for enhanced drug delivery for brain gliomas, 09/01/2009 – 08/31/2010
  • R21 EB0011548-01, Sarvazyan (PI), Diagnostic Technologies Based on Acoustic Radiation Force, 04/01/03 – 03/31/05
  • R21 EB02787-01, Sarvazyan (Co-investigator), Swanson (PI), MR Elastography Using Time Reversed Acoustics, 10/01/2003 -09/30/2005
  • NNL04AB54P, NASA, Sarvazyan (Co-investigator), Sutin (PI), Time Reversal Acoustic Structural Health Monitoring Using Array of Embedded Sensors, 01/16/2004-01/15/2005
  • FA9550-04-C-0068, DoD/Air Force, Sarvazyan (Co-investigator), Sutin (PI), Vibration Based Structural Health Monitoring using Time Reversal Acoustics, 09/15/2004 - 06/14/2005
Patents
  • Sarvazyan AP, Fillinger L, Sutin A. “Focusing of broadband acoustic signals using time-reversed acoustics”, USA Pat No 7,587,291; Sept. 8, 2009.
  • Sarvazyan AP, Emelianov S, “Wireless beacon for time-reversal acoustics, method of use and instrument containing thereof”, USA Pat. No. 7,713,200; May 11, 2010.
  • Sarvazyan AP, “Ultrasound-assisted drug-delivery method and system based on time reversal acoustics”, USA Pat. No. 7,985,184; July 26, 2011.
  • Sarvazyan AP, “Ultrasound diagnostic and therapeutic devices”, US Patent Application No. 13,028,301; Filed Feb 16, 2011.
  • Sarvazyan AP, "Systems for remote generation of electrical signal in tissue based on time-reversal acoustics", USA Pat. No. 8,649,875; Feb 11, 2014
  • Sarvazyan AP, "Leadless system for deep brain stimulation using time reversal acoustics", USA Pat. No. 8,649,876; Feb 11, 2014

Publications and Presentations

Publications
  1. Lewis GK Jr, Guarino S, Gandhi G, Filinger L, Lewis GK Sr, Olbricht WL, Sarvazyan A. Time-reversal Techniques in Ultrasound-assisted Convection-enhanced Drug Delivery to the Brain: Technology Development and In Vivo Evaluation. POMA. 2011 Jul 10;11:20005-20031.
  2. Sinelnikov YD, Sutin AM, Vedernikov AY, Sarvazyan AP. Time reversal acoustic focusing with a catheter balloon. Ultrasound in Medicine and Biology, 2010; 36(1): 86-94.
  3. Sinel’nikov ED, Sutin AM, Sarvazyan AP: Time reversal in ultrasound focusing transmitters and receivers. Acoustical Physics 2010; 56(2): 183–193.
  4. Sarvazyan A, Fillinger L: Arbitrary shaped, liquid filled reverberators with non-resonant transducers for broadband focusing of ultrasound using Time Reversed Acoustics. Ultrasonics 2009; 49(3):301-305.
  5. Sarvazyan A, Fillinger L, Gavrilov L.Time-reversal acoustic focusing system as a virtual random phased array. IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Apr;57(4):812-7.
  6. Sutin A, Libbey B, Fillinger L, Sarvazyan A: Wideband nonlinear time reversal seismo-acoustic method for landmine detection. J Acoust Soc Am 2009; 125(4): 1906-10.
  7. Sarvazyan AP, Fillinger L, Gavrilov LR. A comparative study of systems used for dynamic focusing of ultrasound. Acoustical Physics 2009; 55(4-5):630–637.
  8. Fillinger L, Sarvazyan AP, Sutin A. Time reversal focusing of short pulses. Proc. 2007 IEEE Ultrasonic Symposium. 220-223
  9. Choi BK, Sutin A, Sarvazyan A. Formation of desired waveform and focus structure by time reversal acoustic focusing system. Proc. 2006 IEEE International Ultrasonics Symposium, Vancouver, Canada, 2006: 2177-2181.
  10. Sutin A, Sarvazyan A. Spatial and temporal concentrating of ultrasound energy in complex systems by single transmitter using time reversal principles. Proc. World Congress on Ultrasonics, Paris, 2003: 1019-1022.
Presentations
  1. Sinelnikov YD, Sutin AM, Tsyuryupa SY, Sarvazyan AP. Dynamic time reversal acoustic focusing of ultrasound for biomedical applications. J. Acoust. Soc. Am., 2013, Vol. 133, No. 5, Pt. 2, p. 3586
  2. Sutin AM, Sinelnikov YD, Sarvazyan AP. Advances in biomedical applications of time reversal acoustic focusing of ultrasound. J. Acoust. Soc. Am., 2013, Vol. 134, No. 5, Pt. 2, p. 4033
  3. Sarvazyan A, Gandhi G, Sutin A. Time Reversal Ultrasound Focusing with Electromagnetic Feedback. Abstracts of the IEEE International Ultrasonics Symposium, October 18-21, 2011, Orlando, Florida, USA, 490.
  4. Lewis GK, Olbricht WL, Sarvazyan A, Southard T, Pannullo S, Ultrasound-assisted Convection Enhanced Drug Delivery to the Brain, Proc. AIUM, 2011
  5. Lewis GK, Guarino SE, Sarvazyan A, Olbricht WL, "Ultrasound-Assisted Brain Drug Delivery", Proc. Biomed. Eng. Soc, 2011
  6. Sinelnikov Y, Sutin A, Gandhi G, Sarvazyan A: Time reversal ultrasound focusing to a predefined area using a set of impulse responses. Abstracts of 11th International Symposium on Therapeutic Ultrasound, New York, NY, April 10-13, 2011.
  7. Lewis GK, Olbricht WL, Sarvazyan A: Time reversal techniques in ultrasound assisted deep vein thrombosis treatment: Technology development and in vitro evaluation. J Acoust Soc Am 2011; 129: 2609-2610.
  8. Raghavan R, Poston T, Lewis JK, Gandhi G, Sarvazyan A: Steering acoustic intensity patterns generated by time-reversal, to move therapeutic particles in tissue. J Acoust Soc Am 2011; 129: 2610.
  9. Sutin A, Sinelnikov Y, Gandhi G, Rapoport N, Sarvazyan A: Ultrasound focusing to a predefined area using principles of time reversal acoustics. (Invited). J Acoust Soc Am 2011; 129: 2531.
  10. Lewis JK, Fillinger L, Lewis GK, Olbricht WL, Sarvazyan A. Time reversal techniques in ultrasound assisted convection-enhanced drug delivery to the brain: Technology development and in vivo evaluation. J Acoust Soc Am 2010; 128:2335.
  11. Lewis G, Fillinger L, Lewis G Sr, Olbricht W, Sarvazyan A: Time-reversal techniques in ultrasound-assisted convection-enhanced drug delivery to the brain: technology development and in vivo evaluation. Abstracts of 10th International Symposium on Therapeutic Ultrasound, Tokio, Japan, June 9-12. 2010.
  12. Fillinger L, Kurtenoks V, Lewis Jr G, Sutin A, Sarvazyan A: Time reversal ultrasound system for enhanced drug delivery in rat brain. Abstracts of 9th International Symposium on Therapeutic Ultrasound, Aix-en-Provence, France, Sept 2009: 105.
  13. Fillinger L, Sinelnikov Y, Sutin A, Sarvazyan A: Time Reversal Acoustic receiver. J Acoust Soc Am 2008; 124(4): 2486.
  14. Sarvazyan A, Fillinger L, Gavrilov L: Focusing and steering ultrasound without creating detrimental grating lobes. IEEE International Ultrasonic Symposium, Beijing, Nov. 2-5, 2008.
  15. Fillinger L, Sutin A, Sarvazyan A: Time Reversal Acoustic focusing with random reverberator. J Acoust Soc Am 2008; 123: 3338.
  16. Sinelnikov Y, Vedernikov A, Sutin A, Sarvazyan A: Time Reversal Acoustic focusing using layered membranes structure. J Acoust Soc Am 2008; 123: 3430.
  17. Sarvazyan A: Ultrasonic transducers for imaging and therapy based on time-reversal principles. J Acoust Soc Am 2008; 123: 3429.
  18. Fillinger L, Kurtenoks V, Rosenblum S, Sutin A, Sarvazyan A: Flexible tools for time reversal acoustics focusing applications. J Acoust Soc Am 2007; 122: 3009.
  19. Fillinger L, Sutin A, Sarvazyan A. Time reversal acoustic focusing of short pulses. Abstracts of 2007 IEEE International Ultrasonics Symposium, New York, 2007; 237.
  20. Fillinger L, Sutin A, Libbey B, Sarvazyan A: Varied amplitude nonlinear acoustic method of landmine detection. J Acoust Soc Am 2007; 122(5): 3060.
  21. Sutin A, Libbey B, Sarvazyan A: Nonlinear time reversal acoustic method of land mine detection: experiment and modeling. J Acoust Soc Am 2007; 121(5): 3163.
  22. Sinelnikov Y, Vedernikov A, Sutin A, Sarvazyan A: Time reversal acoustic focusing with liquid-filled reverberator. J Acoust Soc Am 2007; 121(5): 3083.
  23. Sutin A, Kurtenoks V, Sabatier J, Burgett R, ONeil M, Aranchuk S, Libbey B, Sarvazyan A: Time-reversal acoustic focusing of waves produced by seismic vibrators. J Acoust Soc Am 2006; 120: 3369.
  24. Libbey B, Fenneman D, Sutin A, Kurtenoks V, Sarvazyan A: Wide-bandwidth time-reversal techniques for landmine detection. J Acoust Soc Am 2006; 119: 3387.
  25. Sutin A, Libbey B, Sarvazyan A: Phase inversion and two-frequency interaction in nonlinear time-reversal acoustic method of land mine detection. J Acoust Soc Am 2006; 120: 3368.
  26. Choi BK, Sutin A, Sarvazyan A: Comparison of time reversal acoustic and prefiltering methods of focusing of tone burst signals. J Acoust Soc Am 2006; 120: 3282.
  27. Sutin A, Sinelnikov Y, Sarvazyan A. Time reversal acoustic focusing system based on the liquid-filled acoustic resonator. J. Acoust. Soc. Am. 2006; 119: 3413.
  28. Choi BK, Sutin A, Sarvazyan A: Time reversal acoustic focused field and its prediction based on impulse response. Proc 9th Western Pacific Acoustic Conference, Seoul, Korea, 2006.
  29. Choi BK, Sutin A, Sarvazyan A: Formation of desired waveform and focus structure by time reversal acoustic focusing system. Proc 2006 IEEE Int Ultrasonics Symposium, Vancouver, Canada, 2006: 2177-2181.
  30. Sutin A, Libbey B, Kurtenoks V, Fenneman D, Sarvazyan A: Nonlinear detection of land mines using wide bandwidth time-reversal techniques. Ed: Broach JT, Harmon RS, Holloway JH, Jr. Detection and Remediation Technologies for Mines and Minelike Targets XI. Proc SPIE 2006; 6217: 398-409.
  31. Sinelnikov Y, Sutin A, Zou Y, Sarvazyan A: Time reversal acoustic focusing with liquid resonator for medical applications. Trans 6th Int Symposium on Therapeutic Ultrasound International Society for Therapeutic Ultrasound, Oxford, UK, August 30th - September 2nd, 2006; 82-86.
  32. Dos Santos S, Choi BK, Sutin A, Sarvazyan A: Nonlinear Imaging Based on Time Reversal Acoustic Focusing. Congrès Français d’Acoustique, Tours, France, 2006; 359-362.
  33. Palacio D, Bercoff J, Montaldo G, Tanter M, Fink M, Sutin A, Sarvazyan A. 3D shear wave generation in soft tissues using the time reversal kaleidoscopes. J. Acoust. Soc. Am. 2004; 115: 2595.
  34. Sarvazyan A, Sutin A. Generation of ultrasound radiation force with the use of time reversal acoustics principles. J. Acoust. Soc. Am. 2005; 118 (3): 2005.
  35. Sutin A, Sarvazyan A. Advantages of time reversal acoustic focusing system in biomedical applications. J. Acoust. Soc. Am. 2005; 118: 1941.
  36. Haworth A, Kripfgans A, Steele D, Swanson D, Sutin A, Sarvazyan A. Acoustically induced tissue displacement for shear wave elasticity imaging using MRI . J. Acoust. Soc. Am. 2005; 118: 1942.
  37. Sutin A, Roides E, Sarvazyan A. Optimization of time-reversal acoustic focusing. J. Acoust. Soc. Am. 2004; 116: 2568.
  38. Sarvazyan A, Sutin A. Shear wave elasticity imaging with the use of time reversal acoustics. Proc. The Third International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity. Lake Windermere, Cumbria UK, Oct 17-20, 2004: 69
  39. Sutin A, Sarvazyan A, Montaldo G, Palacio D, Bercoff J, Tanter M, Fink M. Broadband time reversed acoustic focusing and steering system. J. Acoust. Soc. Am. 2004; 115(5): 2596.
  40. Sarvazyan A, Sutin A. Application of time reversal acoustics focusing for nonlinear imaging. J. Acoust. Soc. Am. 2004; 115: 2595.
  41. Sutin A, Sarvazyan A. Focusing of ultrasound in composite medium using time reversal acoustics. IEEE International Symposium, Hawaii, October 5-8, 2003: 416.