Bone Ultrasonometry

Based on know-how in the field of medical ultrasound developed by Artann scientists over 20 years of research and under contract with NASA and the National Institutes of Health, Artann Laboratories has developed a family of ultrasonic devices for assessment of bone health and diagnosis of diseases of the skeletal system. Development of Artann's bone ultrasonometer technology to date has been fueled by about $3 million funding. The technology includes several innovations described in the pending and issued U.S. patents assigned to the company.

The fundamental difference between our technology and existing ultrasonometers lies in its simultaneous use of various modes of ultrasonic waves in a wide frequency range; scanning mode examination and multiparametric characterization of bone conditions. Preliminary studies have shown that the innovations implemented in our devices drastically increase diagnostic capabilities in ultrasonic assessment of bone health when compared to conventional bone ultrasonometers.

Bone UltraSonic Scanner™

Bone UltraSonic Scanner™ (BUSS) is a novel diagnostic tool for screening and monitoring of osteoporosis through multiparametric assessment of bone mechanical and structural characteristics.  In addition to osteoporosis, this technology could be used in diagnosis and monitoring a variety of other skeletal conditions, including pediatric bone growth monitoring and drug-induced bone deterioration. Other fields of BUSS applications include assessment of bone health in sports medicine, monitoring condition of skeletal system of astronauts during long-term space missions, and veterinary medicine.

The device was tested in preliminary clinical studies that have demonstrated superior diagnostic capabilities in assessment of bone health when compared to conventional bone ultrasonometers. We are currently looking for qualified clinical and business partners to complete clinical validation of the device and to bring the technology to the market.

References
  1. Tatarinov AM, Egorov V, Sarvazyan N, Sarvazyan A. Multi-frequency axial transmission bone ultrasonometer. Ultrasonics. 2013 Oct 12. doi:pii: S0041-624X(13)00285-0. 10.1016/j.ultras.2013.09.025. [Epub ahead of print] PMID: 24206675.
  2. Egorov V, Tatarinov A, Sarvazyan N, Wood R, Magidenko L, Amin S, Khosla S, Ruh RJ, Ruh JM, Sarvazyan A. Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings. Ultrasonics. 2013 Sep 10. doi:pii: S0041-624X(13)00259-X. 10.1016/j.ultras.2013.08.017. [Epub ahead of print]. PMID: 24070826.
  3. Tatarinov A, Sarvazyan A, Beller G, Felsenberg D. Comparative Examination of Human Proximal Tibiae In Vitro by Ultrasonic Guided Waves and pQCT. Ultrasound Med Biol. 2011 37(11):1791-801.
  4. Tatarinov AM, Egorov VP, Sarvazyan AP: The dual frequency method for ultrasonic assessment of skeletal system. Acoustical Physics 2009; 55(45):665673.
  5. Sarvazyan A, Tatarinov A, Egorov V, Airapetian S, Kurtenok V, Gatt CJ Jr: Application of the dual-frequency ultrasonometer for osteoporosis detection. Ultrasonics 2009; 49(3):331-337.
  6. Tatarinov A, Sarvazyan A: Topography of acoustical properties of long bones: from biomechanical studies to bone health assessment. IEEE Transact on Ultrasonics, Ferroelectrics, and Frequency Control 2008 Jun; 55(6):1287-97.
  7. Tatarinov AM, Sarvazyan NA, Sarvazyan AP: Use of multiple acoustic wave modes for assessment of long bones: Model study. Ultrasonics 2005; 43, 672-80.
  8. Sarvazyan AP, Tatarinov AM: Method and device for multi-parametric ultrasonic assessment of bone conditions. The Journal of the Acoustical Society of America 2003; 113(5):2395.
  9. Sarvazyan AP, Tatarinov AM: Method and device for multi-parametric ultrasonic assessment of bone conditions. U.S Patent No. 6,468,215 2002.
  10. Tatarinov A.M, Dubonos SL, Yanson HA, Oganov VS, Rakhmanov AS: Ultrasonic diagnostics of human bone state during 370-day antiortostatic hypokinesia. Space Biology and Aerospace Medicine 1990; 2, 29-31.
  11. Tatarinov AM, Dzenis VV, Yanson HA: Role of compact bone tissue thickness in the investigation of tubular bones by ultrasonic exponential concentrators. Mechanics of composite meterials 1985; NY, 21(2):342-57.
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